Jose: Lo Celso not fit enough

first_imgJose Mourinho criticised Giovani Lo Celso despite his impressive Europa League showing for Tottenham, declaring the midfielder is not fit enough.- Advertisement –last_img

Jim Goldie expects Euchen Glen to shine at Doncaster | Racing News

first_imgTim Easterby’s three-strong team is headed by Ebor runner-up Glencadam Glory as he bids for a first win in the big race on the card that brings the curtain down on the turf season.“He’s a very good horse. He’s in good form and he goes on the ground,” said the Great Habton handler.“We’re claiming 7lb off him (with Ella McCain) which will be a big plus. He should run well.”Easterby has booked dual champion jockey Paul Hanagan for Aasheq, who makes a quick reappearance after finishing second at Redcar on Tuesday.“He was a little unlucky the other day,” said Easterby.“He just got shut in a little bit and he didn’t get a run, but he gets the trip and he should have a good chance.”Bollin Joan, the mount of Duran Fentiman, completes Easterby’s trio. The five-year-old mare steps up in class after winning for the third time this season at Catterick last month.“She is a few pounds out of the handicap, but she goes on the ground, gets the trip and has a small weight so she could have a chance,” he said.Joe Tuite landed this prize with Litigant in 2015 and expects Surrey Pride to put up a good show.“He seems good. I think the ground was too soft at Newbury last time, he didn’t seem to handle it. He couldn’t get his feet out of the ground,” said Tuite.“We’re hoping for a better performance this Saturday.“It’ll be his last run of the season, so let’s hope he can run a nice race.”He added: “Litigant was different class, a legend of a horse. They are hard to follow, but this is a good horse and he’s one for next year.“I’m not worried about the trip at all. We’re hopeful.”Ian Williams reports Kingbrook to be in prime condition as the three-year-old bids to follow up last month’s Newmarket success.“He’s in good shape, His preparation has gone well and we couldn’t be happier with him,” the Alvechurch trainer told Sky Sports Racing.“I was worried about him during the race as he looked to be running a bit too free, but Richard (Kingscote) gave him a great ride. He managed to hang on to enough and he finished very strongly. It was a nice step up in trip and one that suited well.”William also saddles Everything For You, whose last race came over hurdles on this course in January.“We were getting him ready for the race last year and it was abandoned due to the flooding at Doncaster,” he said.“He went hurdling and we were unlucky not to get a prep run into him at Doncaster recently. He takes his chance and he finished ninth in the race in 2018, so we’d be hopeful of a nice run from him.” – Advertisement – “He’s going to have a lump a lot of weight again, but he is a Group horse in a handicap and is rated accordingly.“He’s in good order. He should like the ground, he’s won over the course and distance so it should all be fine.“He won’t know he’s got the weight on. Win, lose or draw, he’s had a great season. It will take a decent horse to beat him.”- Advertisement – That success came in the Old Borough Cup at Haydock, and he has gone up 8lb in the ratings since then to 109.“It’s a proper old-fashioned handicap with top-weight of 9st 10lb down to 8st, you don’t usually get those these days,” said Glasgow-based Goldie.“It’s back to the days of old when horses on 8st used to get in these races.- Advertisement – Jim Goldie believes Euchen Glen has plenty in his favour as he bids to end a successful season on a high in the Betfair November Handicap at Doncaster on Saturday.The seven-year-old has taken a brace of Group Three races – the Cumberland Lodge and the St Simon Stakes this autumn – but won a handicap as recently as September.- Advertisement –last_img read more

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China’s draft anti-monopoly rules’ impact on internet firms

first_imgSINGAPORE — China has drafted a slew of new anti-monopoly laws that will likely hit the country’s major internet companies, says Morgan Stanley.It comes as the competitive landscape in China intensifies and tech giants continue to fend off new rivals that are taking away chunks of their market share, according to a report by the investment bank.China’s bureau for regulating monopolies — the State Administration for Market Regulation (SAMR) — issued draft rules on Tuesday to stop anti-competitive practices in the internet sector. It said the laws are aimed at protecting fair competition in the market and safeguarding consumers’ interest.- Advertisement – SAMR is seeking public feedback on the draft rules until Nov. 30.“We believe potential implementation of the new antitrust regulations has negative implications for major Internet companies with dominant positions across segments,” Morgan Stanley analysts said in a note on Wednesday.It is likely due to rising risks of competition, lower barriers to entry, and higher hurdles for industry consolidation from future mergers and acquisitions.- Advertisement – – Advertisement – “That said, competition has already intensified in recent years, with ‘incumbents’ (e.g., Alibaba, Tencent) losing market share to ‘disruptors’ (e.g. Pinduoduo, Bytedance), so the consequences will likely be less meaningful given reduced dominance across segments compared to a few years ago,” they added.Chinese tech shares took a beating on Wednesday, a day after the draft regulations were announced, and the biggest tech names saw $280 billion wiped off their market value within days.Here are five internet companies that will be negatively impacted by China’s potential anti-trust laws, according to Morgan Stanley.AlibabaThere have been periodic complaints of merchant exclusivity on e-commerce platforms, including on Alibaba’s Tmall platform. The Financial Times reported earlier this year that some merchants were told they would be pushed off Tmall if they used a rival platform — a local home appliance manufacturer even sued Alibaba over it, according to a 2019 report from Chinese media Caixin.But the new proposed regulations will not have as much impact on the e-commerce giant today as it would have had years ago, Morgan Stanley pointed out.“This is because of the already fierce competitive environment in e-commerce nowadays,” the analysts said, adding that some of Alibaba’s market share have already been chipped away by competitors. A logo of Ant Group is pictured at the headquarters of the company, an affiliate of Alibaba, in Hangzhou, Zhejiang province, China October 29, 2020.Aly Song | Reuters The draft law mentions the use of subsidies and discounts may potentially deter fair competition, which could affect “Alibaba’s promotional activities, although to what extent such subsidies will be regarded as a violation of antitrust rules remains uncertain,” the analysts said.TencentTencent has dominant presence in areas like online gaming, social network, online music, video and online reading through China Literature.The company’s “focus on online entertainment involves a wide range of content innovation and can be less relevant to antitrust scrutiny,” the Morgan Stanley analysts said. “Thus, the impact on Tencent could be relatively manageable except for the potential misuse of user data across platforms, or blocking competitors access to the WeChat ecosystem.”China’s most popular messaging app WeChat — which has over 1.15 billion monthly active users — is owned by Tencent. Though the app started out as a messaging service, users can now do everything on it from making payments to hailing a ride, or even booking flights.Rising competition from video-sharing app ByteDance has reduced the amount of time users spend on Tencent’s platforms, which could also alleviate “certain concerns over Tencent capturing a majority of user mind share in China,” the analysts wrote.Still, the new rules could create more hurdles for Tencent when it comes to future mergers and acquisitions — “an effective method” for the company to build up its ecosystem of various services and platforms.PinduoduoPinduoduo is the fast-growing challenger to Alibaba and JD.com in China’s hypercompetitive online shopping market.“Should the rules eventually limit the use of subsidies provided by platforms, we think that the potential limitation will affect Pinduoduo in particular, because ‘Rmb10bn subsidy’ is one of its central strategies to drive user engagement,” the Morgan Stanley analysts said.Pinduoduo said last year that it launched a 10-billion-yuan ($1.5 billion) initiative with sellers and gave out coupons and subsidies to customers on its platform.JD.comJD.com, another major e-commerce name in China, also employs a subsidy plan as part of its promotional activities but it does not play as crucial a role for the company as it does for Pinduoduo, according to the analysts.Still, they said, the new anti-monopoly rules could reduce JD.com’s bargaining power over its suppliers in the future.Meituan DianpingMeituan Dianping is an online platform with services ranging from food delivery to ticketing.The company solidified market share in the food delivery business, competing against Alibaba-owned Ele.me, by capturing a higher portion of exclusive restaurants on its platform, according to the Morgan Stanley analysts.“We note the potential implementation of new antitrust regulations could also weigh on Meituan’s take rate charged to merchants,” they said, adding, “On the other hand, Meituan has been shifting gears to focus on promoting a food delivery membership program to cultivate user behavior and raise order frequency.”With fewer restaurants in China opting for platform exclusivity, it could mitigate certain concerns about the new antitrust regulations, according to the analysts. – Advertisement –last_img read more

Study implies broader risk for vCJD in UK

first_img Ironside JW, Bishop MT, Connolly K, et al. Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study. BMJ 2006 May 20;332:1186-8 [Full text] Aug 13, 2004, CIDRAP News article “Study implies many more vCJD cases may emerge in UK” Both positive samples were found to be of the VV type, constituting the first evidence that patients from this genetic subgroup could be infected. Previous studies had detected only MM types among those infected with vCJD, except for one person who had the MV type and apparently acquired vCJD as a result of a blood transfusion. Ironside and colleagues analyzed the DNA from samples that had tested positive in earlier immunohistochemical studies of vCJD prevalence in the UK. They had examined a total of 12,674 tissue samples (11,109 appendices, 1,565 tonsils) of patients who had had surgery from 1995 to 1999. Three samples were positive for vCJD. The investigators suggest that their findings may mean that people who are infected with vCJD and have a VV type may have a prolonged incubation period, during which the disease could spread either via blood donations or from contaminated surgical instruments used on the individuals during the asymptomatic phase of the illness. Variant CJD was first identified in the UK in 1996. Some early estimates of potential deaths were as great as 136,000, but these were subsequently revised downward when additional studies detected far fewer than the number of cases expected on the basis of experimental disease modeling. Currently, the UK has 161 cases of definite and probable vCJD, with 5 additional patients who are still alive. Jun 1 Eurosurveillance Weekly report “Evidence of a new human genotype susceptible to variant variant CJD”http://www.eurosurveillance.org/viewarticle.aspx?articleid=2965 Researchers in the UK had believed that the type of prion protein gene (PRNP) an individual carried (genotype) played a role in susceptibility to the disease. All of the previous deaths from vCJD had occurred in patients who had an MM genotype, or two copies of the M version of the prion gene (PRNP), according to the report. Individuals who carried at least one copy of the V variant of PRNP (MV or VV genotypes) were thought not to be at risk of contracting vCJD. They constitute about 58% of the British population, according to the article. Jul 22, 2004, CIDRAP News article “Another UK patient might have caught vCJD from blood” Ironside and his group had also investigated the case of the patient who developed asymptomatic vCJD infection after receiving blood from a donor who later fell ill with vCJD. The blood recipient had the MV genotype. (The recipient died of unrelated causes, but disease-associated prion protein was found on autopsy.) The report in 2004 highlighted a potential disease risk to others from blood given by donors with asymptomatic, undetected vCJD. The new study, by James W. Ironside and colleagues, has changed thinking about susceptibility to vCJD and has renewed concern about its transmission. The patient samples they analyzed had the VV version of the prion protein gene, a type previously thought to confer protection against vCJD. Although the authors caution against overinterpretation of the results, they assert that their findings may mean that virtually all United Kingdom (UK) residents are at risk for vCJD. June 12, 2006 (CIDRAP News) – More people in Britain may be at risk for contracting variant Creutzfeld-Jacob disease (vCJD) than previously thought, according to a study published in the May 20 issue of the British Medical Journal. The disease is linked to eating meat infected with bovine spongioform encephalopathy (BSE), or mad cow disease. It involves proliferation of a prion protein in the brain, producing plaques and eventually causing death. The authors write that the questions concerning transmission during asymptomatic state in vCJD emphasize the need for continued surveillance for the disorder in the UK and the need for disease modelers to assume that people of all PRNP genotypes are susceptible to vCJD. The researchers extracted DNA from two of the three positive samples; the third did not have sufficient material to obtain DNA. Polymerase chain reaction and restriction analysis was used to detect the genotype of the patients’ PRNP at codon 129. See also:last_img read more

Japan, Thailand face H5N1 in birds again

first_imgJan 16, 2007 (CIDRAP News) – Avian influenza has flared again in the poultry populations of two Asian countries that had enjoyed prolonged quiet periods—Japan and Thailand—as authorities battled spreading bird outbreaks in Vietnam.Japan’s farm ministry today confirmed the country’s first H5N1 avian flu outbreak in chickens in nearly 3 years, Reuters reported. According to an outbreak report from the World Organization for Animal Health (OIE), 3,800 birds on a farm in the Miyazaki prefecture in southwestern Japan died of the disease. Authorities are culling the remaining 8,200 birds.No human cases or additional poultry outbreaks have been reported, Reuters said. Japan has never reported a human H5N1 case.A prefecture official told Reuters authorities would inspect 11 chicken farms within a 6-mile radius of the affected poultry farm and take blood samples from the birds. An initial report on the findings was expected later today.Similar checks are being conducted in other parts of the prefecture and around the nation, Reuters reported.Yesterday Thailand confirmed its first H5N1 outbreak in 6 months, affecting ducks in the country’s northern province of Phitsanulok, according to an OIE report. A farm owner notified livestock officials Jan 11 of mass duck deaths, the Bangkok Post reported today. The OIE report said the disease killed 100 ducks; 1,970 were destroyed.Agriculture Minister Yukol Limlamthong said the latest outbreak points to problems with duck-farm management. Many farmers ignore livestock officials’ warnings against free-range duck farming, which heightens the ducks’ exposure to the virus.The outbreak affected 5-month old Khaki Campbell ducks that were free to feed on nearby rice fields during the day and were housed at night. The report noted that wild birds in the area feed alongside the ducks during the day.Authorities ordered close surveillance of a 5-km area around the infected farm and are keeping a close watch on flood-affected provinces in northern and central Thailand, the Post reported.Lab tests are being conducted to determine if an “N1virus” detected in wild birds in Thailand’s central Suphan Buri province is H5N1, Chaweewan Leowijuk, a Thai livestock official, told Thai News Agency (TNA) today.No human infections have been reported so far, TNA reported. Another livestock official, Methee Ket-adiorn, told TNA all provinces will set up “war rooms” to assist with surveillance and rapid response.Thailand has the world’s third highest number of human H5N1 cases, 25.Meanwhile, in Vietnam the number of Mekong Delta provinces reporting poultry outbreaks recently grew to 7, Agence France-Presse reported Jan 14. The government’s television network reported that the lethal H5N1 strain killed 130 ducks in Soc Trang province and 800 ducks in Tra Vinh province.The country has been battling dozens of outbreaks in the Mekong Delta since early December, but no human cases have been reported since November 2005.In Indonesia, where 5 human cases have been confirmed this month, a scientist is reporting a survey suggesting that 1 in 5 stray cats is carrying the H5N1 virus, Japan’s Kyodo News reported yesterday.C.A. Nidom, a molecular biologist at the University of Airlangga, told Kyodo News he tested 500 feral cats on Java island and in Lampung province of Sumatra island from September to December 2006 and found that 100 carried the virus. He said he reported his results to the Indonesian Health Ministry, which has not published the results.”I’m worried that the virus will be more easily transmitted to humans because the body temperature of mammals like cats is similar to that of humans,” he was quoted as saying.I Nyoman Kandun, director of disease control and environmental health at Indonesia’s health ministry, told Kyodo News he had not received any information about Nidom’s research. He added that there are many unproved “rumors” about avian flu.The H5N1 virus has been detected in stray cats in Indonesia before. In October, researchers from the Indonesian Environment Information Center in Yogyakarta announced that stray cats had caught the H5N1 virus from infected poultry at live marketsOther documented instances of cats infected with the H5N1 virus include house cats in Germany, Thailand, and Austria, and a leopard and tigers at a zoo near Bangkok. However, the role of cats in transmitting the H5N1 virus is not known.The World Health Organization said last year that no human cases have been linked to diseased cats. However, Albert Osterhaus, a virologist with the Erasmus Medical Center in the Netherlands, said cat-to-human transmission was theoretically possible and that cat-to-cat transmission had been shown in a laboratory setting.See also:OIE report on Japanese poultry outbreakOIE report on Thailand duck outbreaklast_img read more

States sound alarms over measles cases

first_imgApr 21, 2009 (CIDRAP News) – Health officials in the Washington, DC, area today said they were working to identify people who may have been exposed to a patient with measles, as officials in other states, including Virginia, Iowa, and Pennsylvania, were responding to three other recent measles exposures.The measles patient in Washington visited a handful of sites Maryland, Virginia, and the nation’s capital on Apr 4 and 5, which prompted authorities in all of the jurisdictions to issue public heath alerts urging those who think they may have been exposed to call in to emergency numbers. The Washington Post reported yesterday that the man, who had not been vaccinated against measles, contracted the virus during a 3-week trip to India.Virginia’s health department announced in a press release today that it had confirmed its first measles case of the year, in a Prince William county resident with no known link to the Washington, DC, case. Virginia officials are in the process of notifying people who may have been exposed to the patient at various sites between Apr 10 and 15.Meanwhile, the Iowa Department of Public Health (IDPH) on Apr 16 reported measles in a child from the northwestern part of the state. The department said that it and local officials were determining who may have been exposed to the disease and investigating the source of the child’s infection. Health officials held a free measles vaccine clinic in Spencer, Iowa, on Apr 18 for those concerned about possible exposure to the virus, according to an Associated Press report.One week earlier, the Pennsylvania Department of Health (PDH) reported that the source of a recent measles outbreak involving six patients in the southwestern part of the state was a traveler from India who arrived in the United States on Mar 7. In an earlier statement the PDH said the confirmed case-patients included three members of a Westmoreland County family—two children under age 5, who had not received the measles-mumps-rubella (MMR) vaccine, and their 33-year-old father, who had received only a single dose of the vaccine as a child.Measles is a highly contagious viral disease that can infect as many as 90% of susceptible contacts, according to the US Centers for Disease Control and Prevention (CDC). Symptoms include a rash, high fever, cough, runny nose, and watery eyes. The virus spreads through coughing and sneezing, and patients can transmit the disease within 4 days before and after rash onset. Complications, ranging from diarrhea to encephalitis, occur in about 20% of patients and can be fatal.The spate of recent measles cases raises concerns like those expressed last year, when measles cases climbed to 138, after averaging about 50 a year between 2004 and 2007, according to the April 17 issue of Morbidity and Mortality Weekly Report (MMWR). As of Apr 11, the CDC had already recorded 14 measles cases this year.Rising measles cases herald a worrisome drop in overall US vaccination rates, the CDC said in an August 2008 MMWR update on the disease. “Measles is one of the first diseases to reappear when vaccination coverage rates fall,” the agency said.Through the end of July last year, the CDC had already recorded 131 measles cases, from 15 states and the District of Columbia. Only 17 (13%) cases were importations, coming from Europe, India, Israel, China, Pakistan, and the Philippines. However, 99 (76%) of the cases had epidemiologic or virologic links to importation. The source in 15 (11%) of the cases could not be determined.The CDC said the number of measles cases reported through July 2008 was the highest since 1996. But the increase was not linked to more imported cases, but rather greater viral transmission after importation into the United States. The authors described a measles outbreak in Washington that had 19 linked cases and one in Illinois that had 30.Such importation-associated cases were occurring largely among school-age children who are eligible for vaccination, but whose parents decline the vaccines for philosophical or religious reasons, the CDC said, citing a recent study that showed in increasing number of vaccine exemptions in school children. Also, the CDC added that many states exempt home-schooled children from vaccination requirements. Last year’s measles outbreaks in Washington and Illinois both occurred primarily in home-schooled children.Last year, the United Kingdom’s Health Protection Agency declared that after a drop in vaccination rates, measles was endemic again, 14 years after the disease was considered eliminated.The CDC predicted that measles importations would continue to cause outbreaks in US communities, especially ones that have large clusters of unvaccinated people.Patricia Quinlisk, MD, MPH, medical director at IDPH, said in the press release that the measles cases serve as a reminder for parents to vaccinate their children. “All Iowans should check their child’s immunization records, as well as their own to make sure their measles vaccinations are up-to-date,” she said.See also:CDC. Notifiable diseases/deaths in selected cities weekly information. MMWR 2008 Apr 17;58(14);376-87 [Full text]CDC. Update: measles, United States, January-July, 2008. MMWR 2008 Aug 22;57(33):893-96 [Full text]April 21 Virginia Department of Health press releaseCDC background on measleslast_img read more

Another study suggests greater novel H1N1 pathogenicity

first_imgJul 13, 2009 (CIDRAP News) – The pandemic H1N1 virus in different animal models causes more lung damage and can replicate efficiently in the trachea and deep in the lungs when compared with its seasonal flu counterpart—a pattern seen in the 1918 pandemic virus—according to a study published today.Though the new report appears to confirm the pathogenicity findings of two studies that appeared Jul 2 in Science, the more severe disease that researchers are seeing in animal experiments runs counter to the mild-to-moderate infection profile in humans.In a multifaceted study that appears in an early online edition of Nature, the group, from Japan and the University of Wisconsin, conducted a host of other experiments—both in vitro and in vivo—to better characterize the risks of the new virus.Yoshihiro Kawaoka, PhD, a researcher from the University of Wisconsin-Madison who led the Nature study, said in a press release that the study may help clear up misunderstandings people have about the new virus. “People think this pathogen may be similar to seasonal influenza,” he said. “This study shows that is not the case. There is clear evidence the virus is different than seasonal influenza.”Animal models show pathogenicity trendsThe research group evaluated pathogenicity in four animal models: mice, ferrets, macaques, and pigs. They used pandemic H1N1 viruses obtained this year from patients in California, Wisconsin, the Netherlands, and Japan, as well as a seasonal H1N1 virus from Japan.They found that the pandemic H1N1 virus replicated more efficiently in the lungs and that it exhibits a different pro-inflammatory cytokine response pattern in infected animals. However, they wrote that more study is needed to understand the relevance of the cytokine findings.In macaques, animals infected with the pandemic H1N1 virus had greater body temperature increases, but body weight loss wasn’t different from animals that were infected with the seasonal flu virus. The new virus replicated efficiently in the lungs and other respiratory organs, similar to highly pathogenic influenza viruses.Pathological examination revealed that the novel virus caused more severe lung lesions that contained type 2 pneumocytes—a finding that has been reported with H5N1 avian influenza viruses.In the ferret model, the group found more severe bronchopneumonia in the animals infected with the pandemic H1N1 virus. Researchers also used ferrets to test transmission, a key factor in human-to-human spread of the virus. They placed ferrets infected with either the pandemic or seasonal flu virus in perforated cages next to, but not touching, cages housing uninfected ferrets.They found that transmission patterns for the novel H1N1 virus were comparable to that of seasonal H1N1 and H3N2 strains. An avian H1N1 virus, however, did not transmit from the infected to the uninfected ferrets.Kawaoka told CIDRAP News that the transmission study was designed to gauge droplet, not aerosol, transmission.To test virus replication of the pandemic H1N1 virus in pathogen-free miniature pigs, they inoculated the animals with either the new virus or a classical swine H1N1 virus. Both viruses replicated efficiently in the respiratory organs of the pigs, though the ones infected with the pandemic strain were asymptomatic, despite having slightly more apparent bronchitis and bronchiolitis.The group suggested that asymptomatic infection, despite efficient viral replication, may explain why no novel H1N1 outbreaks in pigs were detected before the virus surfaced in humans.Antiviral and serology findingsTesting antiviral action against the viruses in mice, the researchers found that the pandemic H1N1 virus was susceptible to licensed neuraminidase inhibitors oseltamivir (Tamiflu) and zanamivir (Relenza), as well as an experimental one called R-125489. An experimental broad-spectrum RNA polymerase inhibitor, called compound T-705, was also effective against the pandemic H1N1 virus.The antiviral compounds were also effective against the seasonal flu viruses, but oseltamivir resistance was seen against seasonal H1N1.In a serology experiment that measured neutralizing activity of blood from a wide range of age-groups against both pandemic and seasonal H1N1, the investigators found no appreciable neutralizing bodies against the novel flu virus in people who were born after 1920.They concluded that infection with the 1918 virus, or a closely related human H1N1 virus, neutralized the novel flu virus. However, they noted that infection with the antigenically divergent H1N1 strains that circulated in the 1920s to 1950s, as well as in 1977, did not.Experts say animal models have limitsVincent Racaniello, PhD, professor of microbiology at Columbia University and author of Virology Blog, told CIDRAP News that the two recent studies in Science both showed that the new H1N1 strain replicates more extensively than the seasonal strain in the lower respiratory tracts of ferrets. However, the replication pattern with the new virus was not associated with significantly higher morbidity.He said the Kawaoka study in Nature had similar conclusions, but it’s not clear what that means for humans.”We have already had over a million—probably several million—human infections with the new strain, and all agree the symptoms are mild, similar to those of seasonal flu,” Racaniello said. “So it’s not clear to me why these results should suddenly make us all fear that the new virus is in fact more virulent than we think.”Perhaps the results underscore the point that animal models are just models and don’t reveal much about human infections, he added.Racaniello cautioned against thinking of serious infections in patients with no known underlying conditions as evidence of pandemic H1N1’s pathogenic potential. Subtle defects that can impair immune response, especially early in infection, can lead to lethal disease in otherwise healthy people, he said.”In other words, you don’t have to have heart disease to have a bad outcome with influenza.””I don’t think the results of any of the three papers should be interpreted to mean that 2009 H1N1 is more virulent than we think it is,” he said, pointing out that there are enough differences among the three studys’ results to cast doubt on any virulence extrapolations in humans.Adolfo Garcia-Sastre, PhD, a virologist at Mount Sinai School of Medicine in New York City, said the Kawaoka study is very comprehensive. “The results are consistent with a more pronounced tropism for the lower respiratory tract, which is of concern,” he said.”However, previous H1N1 immunity in humans may dampen some of the more severe disease seen in animal models, which are naive.”Itoh Y, Shinya K, Kiso M, et al. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 2009 Jul 13 early online edition [Abstract]See also:Jul 13 University of Wisconsin press releaseJul 2 CIDRAP News story “Studies: Novel H1N1 affects deep lung tissue, transmits fairly well”last_img read more

Dubrovnik continues to lower record tourist results

first_imgAccording to the provisional data of the E-visitor tourist check-in and check-out system, Dubrovnik has achieved record tourist results in eleven months this year.From 1 January to 30 November 2017, 1.160.745 tourists stayed in Dubrovnik in all types of accommodation, which is 17% more than in the same period in 2016. There were 3.913.597 overnight stays, or 14% more than last year. In the first eleven months of this year, the most numerous tourists were from the United Kingdom, the United States, Germany, France, Spain, Croatia, Australia, Sweden, Finland and Ireland.Samo u studenom 2017. godine ostvareno je 26 947 dolazaka, što je čak 23 % više nego u istom mjesecu prošle godine, te 63 371 noćenja, što je 22 % više nego 2016. godine. U studenom su najbrojniji bili turisti iz Hrvatske, SAD-a, Albanije, Koreje, Njemačke, a slijede turisti iz BIH, Japana, Tajvana, Singapura i Francuske.  U hotelskom smještaju je od 1.siječnja do 30. studenog ove godine boravilo 627 371 gostiju, što je porast od 5 % u odnosu na prošlu godinu te je ostvareno 2.088 117 noćenja, 3 % više nego prošle godine. U hotelskom smještaju najbrojniji su gosti u deset mjeseci ove godine iz slijedećih zemalja: Ujedinjenog Kraljevstva, SAD-a, Njemačke, Francuske, Hrvatske, Španjolske, Švedske, Finske, Irske te Austrije.In the first eleven months of this year, there were 383 arrivals in private accommodation, ie 531% more than in the same period last year, and 28 overnight stays, which is 1.346.917% more than in 24. The most numerous tourists in private accommodation were from the countries: the United Kingdom, the United States, France, Germany, Spain, Australia, Italy, Norway, Canada and Sweden.Prema privremenim podacima iz sustava E-visitor uključujući i ostvareni promet u nautičkom turizmu, u  Dubrovniku je u prvih jedanaest mjeseci boravilo 1.196.779 turista te je ostvareno 4.164.335 noćenja.<br />
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The Blue Lagoon increased the material rights of workers with the new Collective Agreement

first_imgThe Trade Union of Istria, Kvarner and Dalmatia, the Trade Union of Tourism and Services of Croatia and the Blue Lagoon Administration have completed negotiations on the rights of Blue Lagoon and Istraturist workers for next year, which resulted in equalization of workers’ rights, given the merger of Istraturist dd to Blue Lagoon. That is how it will be from January 1.1.2018, XNUMX. the collective agreement of Plava Laguna dd should be applied to all employees in the company, which will facilitate further operations and guarantee equal rights to all employees.In addition to equalizing the rights from the Collective Agreement, the salaries of individual workers and groups of workers will be further increased, especially workers who work as maids and those associated with them, and their salaries will be increased by an additional 10% on average. Also, it was agreed to increase the basic salary for all workers in the amount of 4% starting from June 1, 2018.In this way, there will be an increase in the total material average rights for workers in the destination Poreč in the amount of almost 5 percent, and the destination Umag over 9 percent. The rights will be completely equalized as early as January 1.1.2018, XNUMX. “At the level of material rights exercised by workers, Plava Laguna is one of the most successful tourist companies in Croatia and we are glad that the intention of the Employer in the future is to maintain or increase the same level in order to achieve employee satisfaction with rewards and maintain competitiveness in the increasingly demanding labor market.”, Point out the Trade Unions of Istria, Kvarner and Dalmatia and add that the collective agreement of the Blue Lagoon is certainly one of the best, if not the best.In addition to the increased salary from June 1.6.2018, 70,00, workers of the now “big” Blue Lagoon can also count on holiday pay of HRK 500,00 gross per day of vacation, one-time payments of HRK 12 gross for June and July, Christmas bonus in the amount of the maximum non-taxable amount, ie a proportional part for workers who have worked for less than 2 months and longer than 600,00 months, a gift in kind in the maximum non-taxable amount which will amount to HRK XNUMX next year, a gift to the child in the maximum non-taxable amount. “We are also pleased with the readiness of the employer to return any savings based on the announced changes in tax regulations to the material rights of workers.“Reports from the Trade Unions of Istria, Kvarner and Dalmatia.Half of the workers are permanently employed, and the work is seasonalOn 20.08.2017. 36% of permanent employees were employed in the company on the basis of one of two types of fixed-term contracts, compared to 64% of fixed-term employees. Already now, based on the concluded contracts, it is possible to determine that on August 20.08.2018, 44. 7% of employees will be employed in the company on the basis of one of two types of fixed-term contracts, 49% of workers will perform work on the basis of employment contracts for permanent seasonal work for a fixed period of three years, while XNUMX% of workers will be employed on the basis of specific time.In 2018, more than 10 percent of the capital budget will be invested in the arrangement and construction of capacity to accommodate workers, according to the Blue Lagoon. More than HRK 50 million will be invested in the construction of 91 new double rooms (HRK 27 million) in Universal (Blue Lagoon resort), 60 new double rooms in Kator in Umag (HRK 18 million), 50 new mobile homes in Stella Maris in Umag (HRK 4,5 million) and 10 mobile homes in Bijela uvala (HRK 900 thousand). “Plava Laguna is continuously improving the rights of its workers, as well as the conditions of accommodation and stay of workers in our destinations. We will continue to increase the quality of conditions, as well as accommodation, because we are aware that development is based on satisfied workers.”, They say from the Blue Lagoon.Related news: APPOINTMENT OF THE MANAGEMENT BOARD OF PLAVA LAGUNA DD POREČlast_img read more