EMGS does not expect that it will be possible to find alternative work for the vessel to replace the delayed project EMGS was awarded a contract for a proprietary CSEM survey offshore Senegal and Mauritania. (Credit: C Morrison/Pixabay.) Reference is made to the stock exchange notification published by Electromagnetic Geoservices ASA (“EMGS” or the “Company”) on 28 June 2019 wherein the Company announced it had been awarded a contract for a proprietary CSEM survey offshore Senegal and Mauritania.EMGS has been advised by the customer that it has decided to postpone the project. It is EMGS’ understanding that the decision is based on the ongoing COVID-19 pandemic.Start of acquisition was planned for March 2020. All further mobilisation activities will be stopped immediately.EMGS does not expect that it will be possible to find alternative work for the vessel to replace the delayed project. Source: Company Press Release
Home » News » Could you do this? 26-year-old estate agent becomes US vlogging star previous nextCould you do this? 26-year-old estate agent becomes US vlogging starSimon Wilson worked at branches in Milton Keynes, London and Kettering before deciding to try and make it big in the US videoing himself getting into famous events. And he’s cracked it.Nigel Lewis21st September 201706,444 Views A former estate agent from Wales has become a video blogging star in the US after blagging his way into the 69th Emmy Awards show held last Sunday in downtown Los Angeles.Rhos-on-Sea born Simon Wilson, 26, who worked for both Milton Keynes agency Creative Estate Agents in Wolverton and Orchards in central London before setting up his own estate agency called Wilson Langley in Kettering, Northants, this year turned to ‘vlogging’ and appearing in TV reality shows.His previous brushes with fame have included meeting Richard Branson at an entrepreneur event in Boston, bumping in to Wolf of Wall Street actor Jonah Hill in Los Angeles and blagging a $100,000 ringside seat for last month’s Mayweather vs McGregor boxing fight in Las Vegas.The video of his antics getting into the fight event have attracted 578,000 views on YouTube, plus he also recently appeared in ITV’s follow-up dating show to Love Island, called Dressed to Impress.Emmy’s AwardsBut his big moment has now come after he videoed himself sneaking into the Emmy’s, which including footage of himself blagging free drinks at getting into the ceremony’s after-show party within the Microsoft Theatre in Los Angeles.Dressed in a cheap evening suit and dickie bow he bought from a charity shop and pretending to be a journalist, Simon managed to blag pictures of himself both holding actor Donald Glover’s Emmy Award, rubbing shoulders with Nicole Kidman and Charlie Brooker and getting snapped with English actress and Mission Impossible star Thandie Newton.Simon now plans to remain in the US and told a North Wales newspaper that he is now talking to several US media outlets and has several more “plans up his sleeve”.“Off the back of these videos, I’m working on something really exciting with a couple of companies in Beverly Hills,” he said. “People’s reactions have been crazy,” he added. “I haven’t been back to the UK yet but the reaction has been great.”Watch Simon’s latest video here:Orchards Simon Wilson Creative Estate Agents September 21, 2017Nigel LewisWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Hong Kong remains most expensive city to rent with London in 4th place30th April 2021
We hope that today’s “IS IT TRUE” will provoke honest and open dialogue concerning issues that we, as responsible citizens of this community, need to address in a rational and responsible way?IS IT TRUE it been alleged that a member of of the Union County Hospital Advisory Board asked the Henderson Community Methodist Hospital administration for a line-item documentation regarding an alledged $20-$23 million dollar cash advancement/loan given to Henderson County Methodist Hospital by Union County Hospital? … it’s been alleged that as of today that the member of the Union County Hospital Advisory Board hasn’t received an answer to his request?IS IT TRUE that it was just announced that another 72 stores owned and operated by the Sears and Roebucks Company will be closing?…it has only been weeks since the Washington Square Sears on Evansville’s eastside was closed in the last round of bloodletting?…for the first quarter of 2018 it was reported by Sears that sales of merchandise is down 34% and sales of services were down 31%?…Sears stock is selling for $2.85 per share yet the company lost $3.93 per share in the last three months?…this means that Sears lost more money in 3 months than they are worth in the market?…Sears in many ways was the first big chain department store to expand nationally and was the beginning of the end for downtowns across the country?…Walmart came along and put a harpoon in the Sears business model and today Amazon is doing the same thing to every retail merchant in sight?…there are those who call Sears, “the Amazon of the 20th Century” and they are accurate?…Sears created a new business model that had broad appeal and obliterated their competition and now they are being obliterated for failing to respond to the digital age of shopping?IS IT TRUE that Courier and Press writer Jon Webb has come out swinging at five decades of leaders of the City of Evansville for failing to address the raw sewage issues before they became a government mandate that will ultimately pick the taxpayer’s pockets for a billion dollars?…Webb is of course correct and the City County Observer has been writing about this negligence for 9 years now?…Webb also attacked the attack upon that First Amendment to the United States Constitution that has been raging across America for roughly ten years?…he very accurately pointed out that attacking the First Amendment in ways that certain factions agree with is seen as progress but that there is massive inconsistency that is corrupted by the stench of politics?…it is a sad state of affairs when we can’t set our tribalism aside and support the only thing that has held our country together for over 200 years and that is the Constitution of the United States of America and all of its amendments?IS IT TRUE that more storms and rains are coming to the Tri-State so Jon Webb, the CCO and anyone with an IQ of over 60 knows this is going to mean raw sewer slime in the streets and the Ohio River?…the trouble is nothing of substance is being done with the exception of the Bee Slough improvements which are 50 years overdue?IS IT TRUE that it has long been known that Vanderburgh County is the suicide capital of the United States?…it has furthermore been known that it is also the Napa Valley of meth and recently a hotbed of heroin abuse?…it was revealed by Brad Byrd recently that Vanderburgh County is also among a group of counties with a disproportionally high level of infant mortality?…this is all saddening but priorities have always been on fun and games projects and tourism that isn’t going to happen given the other things that are going on?…We wonder what is the status of the million dollar plus water and sewer bills that the the owners of the McCurdy still owes the city?Todays “Readers Poll” question is: Are you surprised that Methodist Hospital called off the public meeting scheduled for Thursday at 5:00 PM on the campus of Methodist Hospital?Please take time and read our articles entitled “STATEHOUSE Files, CHANNEL 44 NEWS, LAW ENFORCEMENT, READERS POLL, BIRTHDAYS, HOT JOBS” and “LOCAL SPORTS”. You now are able to subscribe to get the CCO daily.If you would like to advertise on the CCO please contact us [email protected] LinkEmail
Source: Frank DaleFoodservice brand Frank Dale is diversifying into independent retail and direct to public sales.Foodservice brand Frank Dale is moving its frozen occasions food offering into the independent sector as it re-jigs its business model.The Norfolk-based canapés, quiches, pies and cakes company has diversified from supplying wholesalers servicing the hospitality sector, and has started selling direct to both independent retailers and to the general public. Owner Ed Miles explained: “With the hospitality industry being one of the hardest hit during Covid, it was time for the business to think outside the box and concentrate on what we do best, delivering delicious, authentically tasty occasions food but looking at new routes to market.”The new website, Frank Dale Foods Online, lets the company sell direct to consumers with a next-day service, opening up another new distribution channel.Independent retailers, farms shops and delis can order via the Deli Shops website, a marketplace and e-commerce platform dedicated to the independent sector.Ed Miles said that future plans for the brand include the roll out of a new gluten-free range in early 2021, to cater for those with special dietary needs as well as the launch of wholesale packs online.New online retail lines for independents include miniature British classics with a quirky twist for fuss-free Christmas and New Year entertaining.The line-up includes Fish & Mushy Pea Rosti; Beetroot Pastry, Spinach, Feta and Red Pepper Mini Quiche and Mini Yorkshire Puddings.The portfolio also includes a range of larger sharing tarts and quiches such as Caramelised Onion Chutney and Mature Cheddar Tart in Turmeric Pastry; Winter Butternut Squash, Emmental, Red Onion and Spinach Tart and Smoked Salmon, Leek and Dill Tart in Beetroot pastry.A selection of plant based and vegetarian foods mini pies, sharing tarts and mini/ individual quiches are also on offer.A four-strong mini cake collection completes the range.
It was a busy weekend for Spafford in Colorado. First, on Thursday night, the band made their debut at The Ogden in Denver. The following night, they headed to Fort Collins for a Friday evening show at The Aggie that featured a guest spot from Greensky Bluegrass’s Dave Bruzza. On Saturday, the band rounded out their Colorado stint with a special performance, open only to fans who grabbed the “All In” VIP package for the weekend.Spafford Packs The Ogden Theatre On Night One Of Colorado Run [Photos]With only the most fervent of fans in attendance, the band went the extra mile to make the intimate evening a special experience for those in the room. The first of the evening’s three sets saw the band go acoustic in addition to debuting some new material. After opening the show with a duet cover of “Stuck In The Middle With You” performed by guitarist Brian Moss and bassist Jordan Fairless (on the djembe), the rest of the band joined in for stripped down runs through “Leave The Light On”, “Hollywood”, and a new Pearl Jam-like “Untitled” song sung by Fairless. Moss followed up Jordan’s new original with one of his own, labeled as “The Evil Solo” on the Spaffnerds setlist. Finally, “Simon + Lily”, “Mad World”, and “The Remedy” closed out the opening acoustic set.Spafford Welcomes Greensky Bluegrass’ Dave Bruzza For RHCP Cover In Fort Collins [Full Show Audio]When the lights came down for the band’s second of three sets, they looked…different. Turns out, they were: To begin the set, Spafford’s tech crew came out to start playing. Gradually, the members of the band replaced the techs, and proceeded to lay down a 40+ minute improvisational exploration–as they’ve been known to do, most recently with their recent Echo Sessions performance and their all-improv album, Abaculus: An Improvisational Experience.Spafford Releases Live 53-Minute Improv Studio Session And More [Pro-Shot Video]After thanking their crew and taking one final set break, the band returned for their third set of the night. This last set was pure-bred Spafford, as the band jammed through tried-and-true originals like “Seven”, “Walls”, “Dream Jam”, “Todd’s Tots” and “Levilan Shores”. Finally, the band closed things down with an appropriate cover of “After Midnight” for their encore, putting a final exclamation point on an unforgettable show, and an overall successful weekend for Spafford in the Rocky Mountain State.Perpetual Groove Welcomes Spafford’s Andrew “Red” Johnson For Paul Simon In Denver [Setlist]Below, you can view a gallery of photos from Spafford’s memorable Globe Hall show courtesy of photographer Tara Gracer.Listen to full audio of Spafford’s intimate Globe Hall performance courtesy of archive.org user BonoBeats:Spafford’s tour continues on Tuesday, 11/14 with a performance at Crocodile Cafe in Seattle, WA. For a full list of upcoming tour dates, head to Spafford’s website.SETLIST: Spafford | Globe Hall | Denver, CO | 11/11/17 Set 1: Stuck In The Middle With You [ 1 ], Leave The Light On [ 2 ], Hollywood, Jordan’s Untitled Song [ 3 ], The Evil [ 4 ], Simon & Lily, Mad World, The RemedySet 2: Jam [ 5 ]Set 3: Seven > Walls, Dream Jam > Todd’s Tots, Levilan ShoresEncore: After Midnight[ 1 ]: Brian (Acoustic Guitar) + Jordan (Djembe)[ 2 ]: Rest Of Set Full Band Acoustic[ 3 ]: First Time Played, Jordan Solo on Guitar[ 4 ]: First Time Played, Brian Solo[ 5 ]: With: Jon Rose, Crew started jam, band replaced crew members one by one without break in play.[Cover photo by Tara Gracer]Spafford | Colorado VIP Show | Globe Hall | Denver, CO | 11/11/17 | Photos: Tara Gracer Load remaining images
A long-lost poem found in a monastic library transmits across a millennium the ideas of an ancient Greek philosopher, changing the course of thought from the Renaissance through the modern age. The story of 15th-century book hunter Poggio Bracciolini and his rediscovery of Lucretius’ “On the Nature of Things” was captured by Cogan University Professor Stephen Greenblatt in his National Book Award-winning account, “The Swerve: How the World Became Modern.” In a discussion with the Gazette, Greenblatt discussed Bracciolini and the poem as a tale about the power of the arts and the role that the humanities play in transmitting vital ideas across generations.GAZETTE: Lucretius’ poem brought ideas from Epicurus into the Renaissance and spread them all the way out to Darwin and Einstein and Jefferson. How did that happen?GREENBLATT: Epicurus was extremely skeptical of – even hostile to – poetry, art, and what we would think of today as the humanities. One of the few sayings of his that survives is, “I spit on poetry.” He wanted his philosophy to be written in plain, unadorned, prose, and so it’s strange that his disciple Lucretius decided to write his philosophical teachings in the form of a poem. Why did he do this?Lucretius likens his poetry to smearing honey around the lip of a cup so that people can swallow what would otherwise be bitter – the way you might do to give medicine to a child. Students of literature are often slightly uncomfortable about that explanation because you don’t want to think of poetry as a kind of adornment, a little sweetener. You want to make a different kind of claim for its power. But in fact in the case of Lucretius it may be that the poetic form actually made the content more palatable and thus helps to answer to the question you ask: How did this thing survive and make it back into circulation after 1417? This poem came back not as a school of philosophy that people were interested in. On the contrary, they thought the ideas were grotesque or weird or simply incomprehensible, but they thought the poetry was beautiful.GAZETTE: So if it wasn’t a powerful poem, the ideas that it transmitted across time may not have survived.GREENBLATT: If the set of propositions had had no aesthetic form, the history of its reception would have been a different one, though it is difficult to know quite what it would have been. What we do know is that when it came back, it was exciting because the form in which it was written, a beautiful poem in classical Latin hexameters, seemed to people to be powerful and important.The scholars who began to edit him in the 16th century said, don’t worry about the ideas, which are horrible, but just appreciate how great the poem is. They wanted to separate the two things completely to get themselves past prohibitions against even contemplating the idea that the universe had no creator or designer, that there was no overarching purpose to anything, that humans weren’t the center of existence, that the universe consisted of infinite numbers of atoms in a void banging together for no purpose. Lucretius’ poetic skill enabled readers to grapple with what they might otherwise have simply rejected in disgust. This is one of those great, rare moments that we dream about, a moment in which there’s a perfect conjunction of philosophical, scientific power and high art.GAZETTE: What are some of the specific literary qualities of this poem or this poet?GREENBLATT: I don’t want to pretend to be an expert in classical prosody. (I can stumble along, but there’s a whole other life involved in understanding how those hexameters work.) But, even from my somewhat primitive comprehension, Lucretius has a wonderful style. He’s a particularly brilliant, elegant fashioner of metaphors, with a delicacy and precision that are unusual. The poem begins with a magnificent, ecstatic hymn to Venus, the goddess of love. That’s the hymn that inspired Botticelli. It’s a great, erotic celebration of a universe in which everything is conjoining, coming together to reproduce, to thrust forward into the future, to celebrate joy and beauty, to ensure peace over war. That was all a metaphor for Lucretius. He didn’t believe Venus existed, at least in the mythological way he represents her. He fashions a metaphor for a universe in which – as he was imagining it – innumerable, invisible atoms were moving, colliding, and connecting. Metaphors in his work turn out to have a kind of richness that they always have in great art. They have a life of their own.GAZETTE: Let’s follow that thought. In your previous book, Will in the World, you dwell on Falstaff and you talk about the mysterious inner principle of vitality in that character, which is something that has kept it alive to readers for centuries. How in the craft of writing are some characters or ideas imbued with that vital spark?GREENBLATT: Shakespeare thought through and about people and narrative. His way of connecting to the world – of conveying what he wanted to convey – was through stories and through the invention of characters who seem as real as anything that’s ever existed. That for him is where vitality lay – in personhood. For Lucretius, the vitality doesn’t exist in personhood. There are no characters.There’s a person Lucretius is addressing called Memmius, and the poet himself speaks at various moments in the work as “I,” but this is not a writer who invents unforgettable people. Instead, he does something that, as the great Harvard philosopher George Santayana observed, has almost never been done before or since. He manages to convey a set of scientific and philosophical ideas with the intensity or force that you associate with literary vitality – with Virgil or with Shakespeare or with Homer. It doesn’t work in every line of Lucretius’ long poem. But when it works, it works because he somehow is able to give you the sense that the material world that he’s fascinated with – the world of atoms and emptiness – is itself surging up and coming alive in the work.So when he writes that the urgency of sexual desire is like blood spurting from you when you’re wounded, or when he describes the weird combination of longing and frustration that comes with actually wanting to penetrate and enter the person whom you desire, you’re at a level of apprehension – vitality, if you want – that is extremely rare. The poet Yeats said that Lucretius wrote the greatest description of sexual intercourse ever written. This achievement has to do not with a merely topographical account of what happens but with a poetic apprehension of what the urgency is – what the experience feels like from the inside. And he does it not only there, in the passages about sex, but even when he is thinking about what appear to be purely theoretical and abstract questions.Lucretius has an elaborate, quite famous account of how atoms are like letters in an alphabet. By themselves they don’t mean anything, but they can go in infinite numbers of combinations and make infinitely different meanings. To think of that connection between letters and atoms and to make good on the connection in poetry is very characteristic of his genius.GAZETTE: You led the University’s Arts Task Force, which advocated for embracing the creative work of the arts as an irreplaceable instrument of knowledge. Is it important, do you think, to be teaching the craft as well as how to analyze these works from the point of view of the humanities?GREENBLATT: For much of my professional career, I didn’t encourage art-making as a cognitive activity. I think it’s entirely possible to capture things that are quite important about art, whether literary art or painting or drawing or sculpture, without doing it, just as you can understand aviation without building a plane.That said, partly as a result of the work for the Arts Task Force, I began to see more and more that I had been missing a dimension in my own teaching, that I could get my students to experience and understand things that were difficult to reach without engaging in the craft. I don’t make such assignments in every course I teach, but in lots of the courses I teach I have moved in that direction – to ask my students to do various forms of art as a cognitive exercise.I think it goes back to the questions that you were asking me about Lucretius. When Lucretius talks about honey smeared around the cup, he makes it sound as if he thought poetry was simply something you added after you concocted the medicine. You open the honey jar and put it around to get people to swallow it. But that’s not what happens. What happens is that a whole set of things are articulated and released only in the making of the art.What was liberating for me about this particular aspect of my teaching is that it enables me to draw on my own experience as a writer in my academic work. I don’t know fully what I want to say until I actually write it. Though I’m not completely lost and sitting in front of a blank page, I can only understand what I mean when I’m actually trying to fashion it persuasively in prose. The writing itself carries a lot of the intellectual weight – figuring out how the sentence could possibly work, how the paragraph could have a form that would make sense, how one page could lead to the next page. These are intellectual enterprises.GAZETTE: In the public discourse lately, there have been a lot of questions about the value of a college education. It seems easier to quantify the value of the skills a student acquires if he or she is studying in the sciences or some other disciplines. How should we think about the value of the humanities?GREENBLATT: There’s an amazing passage in Darwin’s autobiography in which he says that as a young man he used to like to read Shakespeare, but that he tried it recently and just felt nauseated. He asks himself why he felt nauseated and he concluded that he had spent his whole life taking enormous bodies of natural history information and abstracting a set of principles. That enterprise of abstraction or reduction seems to have made him resistant now to literature, poetry, painting, and so forth. Darwin writes that he should have tried to keep the art-loving side of himself up, by giving himself at least a little bit of exposure to art every day. But it is too late now, and he regrets it, since he feels he has lost access to a deep pleasure.Now, that’s partly local to Darwin, but it doesn’t concern him alone. There is an interesting tension between the humanities and the procedures of the sciences, the impulses of art and the enormously powerful reductivist impulse of the sciences.It’s the purpose of the sciences to come up with a set of workable, abstract principles, and humanities tend to be more interested in aspects of experience – what it feels like to be X or Y. What if you could divine what it actually feels like to be a dying, old man in the case of King Lear, or to be a late adolescent in the grip of a terrible parental injunction, in the case of Hamlet. You can try to line the two things up — art and science — and we have been talking in the case of Lucretius about a moment at which the literary impulse and the scientific impulse seem surprisingly integrated, but actually lots of times they’re not integrated at all.Most often in fact they’re pulling in very, very different directions: In the case of the natural and physical sciences toward increasing abstraction; in the case of the literary toward an experiential record that resists abstraction. GAZETTE: In many ways, the story of Poggio is a story about the power of the humanities – his discovery of Lucretius’ poem inspired some of the most influential figures of the Renaissance, and continued to influence prominent thinkers for centuries.GREENBLATT: Yes. He himself might have been quite unhappy about this particular swerve. Everything suggests that in many ways he was rather conventional in his beliefs. This is a person who, as a bureaucrat in the Vatican for 50 years, took Communion every day, didn’t imagine himself drastically rocking the boat, lived a rather cynical life in the world – 14 illegitimate children, a late marriage with more children on the way, wanting to get some money and buy a fancy house and property in Terranuova. And he lived in a world that would have made Gordon Gekko look like Mother Teresa. These were very rough times that he lived in with very cynical people. The Papacy has always had its moral ups and downs as an institution, but he was at the center of it when it was at its most spectacular nadir in the early 15th century. The person for whom he became apostolic secretary was arguably the worst Pope in the history of the Papacy, which is no small achievement. The cardinals themselves felt eventually they had to throw him into jail. Poggio is a poor guy who wants to make it in a large, very cynical, bureaucratic institution, and he does make it to a very high position. There’s no reason to expect anything but that he’ll completely go under morally, and he does much of his life spend, as it were, under water holding his breath.But he has an odd feature to his personality, which is that he’s obsessed with finding ancient books. He doesn’t have to do this. He’s not making his big fortune from it. But he holds onto a desire that is for him what he calls in his work again and again, “freedom.”So he maintains throughout his life this one part of himself – the part that is associated with what we call the humanities – that centers on his interest in the inheritance from the ancient past and what its beauty and force could still be after 1,400 years. I think it keeps him from succumbing to the corrosive acid-bath in which he worked. Most people give up at a certain point. I mean, they get by but they give up most of anything that would actually be worth anything outside the immediate orbit of their well-being and their immediate family’s well-being. But Poggio held on to this peculiar thing. It’s what kept him going.There’s a moment I write about in my book, to me utterly fascinating, in which Poggio’s not only present at but in some sense he’s necessarily colluding in the entrapment of John Hus and Hus’ assistant, Jerome of Prague. And they’re burned at the stake. It’s clear from the letters that Poggio’s uncomfortable about the situation, where the church leaders promise the heretics safe passage – just a free and frank conversation about their views. But once they get their hands on them, they kill them. And then if you read the account just a few weeks later of what it means for Poggio to find an ancient manuscript, you realize that he’s trying to pull himself up out of his mire into something that would seem like it would be worth a human being’s effort.We’re the lucky ones because, without exaggerating the virtues of Harvard, and without getting sentimental about universities in general, we know that these are places that are actually genuine goods of our world. We don’t have to spend our lives, I think, agonizing about whether the institutions that we’re part of are actually fundamentally designed for human well-being and for the good of the world. But most people don’t live in such privileged circumstance, and Poggio certainly didn’t. He lived in far too cynical and desperate a world, and his peculiar passion for ancient books helped him maintain some moral compass in his life.GAZETTE: At the end of the book, you note that Thomas Jefferson owned at least eight editions of “On the Nature of Things,” and it seems that you’re suggesting that the founding of America in the language of the Declaration of Independence was, in a way, an Epicurean endeavor. Is that taking the idea too far?GREENBLATT: Let us say something happens – no one in Henry VIII’s time would have thought that the “pursuit of happiness” was a goal that the state would be interested in for its citizens. First of all, if you’re Henry VIII, you think of yourself as dealing not with citizens but with subjects, and your subjects have obligations, as you may have obligations toward them. But in any case, these obligations, insofar as they were registered at all, did not include enabling the pursuit of happiness.So the question is where does this weird idea – pursuit of happiness – come from? The origins usually are traced to “life, liberty, and property,” which is the Lockean formulation that the Virginia constitution had used, but Jefferson, when he is writing the Declaration changes it to this very peculiar phrase – pursuit of happiness. Does he get it directly from Lucretius? No, not really. Lucretius and the Epicureans didn’t think that was a likely possibility for the life of a citizen in the Athenian state or in the Roman state. Epicurus said what you should do is withdraw into your garden and think about atoms and emptiness and nothing else. This might lead to philosophical pleasure, but it was a pleasure you could have not in the public arena but in the garden. And Lucretius had a similar response: Let’s give up the idea of service to the Roman state, he suggests, along with the greater glory of our armies, and the weird, horrible bloodshed in the Coliseum. Let’s withdraw into the philosophical garden — in his case, let’s say, these beautiful villas in the Bay of Naples, around Herculaneum or Pompeii.So they didn’t imagine a state that could provide the pleasure that the philosopher seeks. What I’m suggesting at the end of my book is that an amazing thing happens 1,800 years later. Jefferson has the idea that an entire society – through its political community – could be organized not in the service of sacrifice to god, or the imperial power of the state, but its citizens’ pursuit of happiness. That’s a fundamentally Epicurean idea but an Epicurean idea that’s been magnified now to the goal of an entire society. It is simultaneously indebted to this great philosophical tradition and it’s a swerve, as it were, from the tradition itself.GAZETTE: And in some way, all thanks to one rediscovered poem.GREENBLATT: Would we have got to this – something like the place we’re in now — if the discovery hadn’t happened? I don’t know. But this is the way it actually took place, with Poggio Bracciolini one day taking a book off a shelf in a monastic library.
They say we can’t escape our past — no matter how much we change, we still have the memory of what came before. The same can be said of our cells.Mature cells, such as skin or blood cells, have a cellular “memory,” or record of how the cell changed as it developed from an uncommitted embryonic cell into a specialized adult cell. Now, Harvard Stem Cell Institute researchers at Massachusetts General Hospital (MGH), in collaboration with scientists from the Institutes of Molecular Biotechnology (IMBA) and Molecular Pathology (IMP) in Vienna, have identified genes that, when suppressed effectively, erase a cell’s memory, making it more susceptible to reprogramming and, consequently, making the process of reprogramming quicker and more efficient.The study was recently published in Nature.“We began this work because we wanted to know why a skin cell is a skin cell, and why does it not change its identity the next day, or the next month, or a year later?” said co-senior author Konrad Hochedlinger, an HSCI principal faculty member at MGH and Harvard’s Department of Stem Cell and Regenerative Biology, and a world expert in cellular reprogramming.Every cell in the human body has the same genome, or DNA blueprint, explained Hochedlinger, and it is how those genes are turned on and off during development that determines what kind of adult cell each becomes. By manipulating those genes and introducing new factors, scientists can unlock dormant parts of an adult cell’s genome and reprogram it into another cell type.However, “a skin cell knows it is a skin cell,” said IMBA’s Josef Penninger, even after scientists reprogram those skin cells into induced pluripotent stem cells (iPS cells) — a process that would ideally require a cell to “forget” its identity before assuming a new one.Cellular memory is often conserved, acting as a roadblock to reprogramming. “We wanted to find out which factors stabilize this memory and what mechanism prevents iPS cells from forming,” Penninger said.To identify potential factors, the team established a genetic library targeting known chromatin regulators — genes that control the packaging and bookmarking of DNA, and are involved in creating cellular memory.Hochedlinger and Sihem Cheloufi, co-first author and a postdoc in Hochedlinger’s lab, designed a screening approach that tested each of these factors.Of the 615 factors screened, the researchers identified four chromatin regulators, three of which had not yet been described, as potential roadblocks to reprogramming. In comparison to the three- to fourfold increase seen by suppressing previously known roadblock factors, inhibiting the newly described chromatin assembly factor 1 (CAF1) made the process 50- to 200-fold more efficient. Moreover, in the absence of CAF1, reprogramming turned out to be much faster: While the process normally takes nine days, the researchers could detect the first iPS cell after four days.“The CAF1 complex ensures that during DNA replication and cell division, daughter cells keep their memory, which is encoded on the histones that the DNA is wrapped around,” said Ulrich Elling, a co-first author from IMBA. “When we block CAF1, daughter cells fail to wrap their DNA the same way, lose this information, and covert into blank sheets of paper. In this state, they respond more sensitively to signals from the outside, meaning we can manipulate them much more easily.”By suppressing CAF1 the researchers were also able to facilitate the conversion of one type of adult cell directly into another, skipping the intermediary step of forming iPS cells, via a process called direct reprogramming, or transdifferentiation. Thus, CAF1 appears to act as a general guardian of cell identity whose depletion facilitates both the interconversion of one adult cell type to another as well as the conversion of specialized cells into iPS cells.In finding CAF1, the researchers identified a complex that allows cell memory to be erased and rewritten. “The cells forget who they are, making it easier to trick them into becoming another type of cell,” said Cheloufi.CAF1 may provide a general key to facilitate the “reprogramming” of cells to model disease and test therapeutic agents, IMP’s Johannes Zuber explained. “The best-case scenario,” he said, “is that with this insight, we hold a universal key in our hands that will allow us to model cells at will.”
To Roger Huang, the infrastructure of one of the nation’s top business schools looks a lot like the global financial markets he has spent his career studying. On March 1, Huang shed the word “interim” in his title to take on responsibilities as the Martin J. Gillen Dean of the Mendoza College of Business, succeeding Carolyn Woo. A member of the Notre Dame faculty since 2000, Huang taught in the Finance department and specializes in international financial management and financial market microstructure. Huang said the interactions within a given financial marketplace are very similar to the educational transactions that take place daily in the College, except the participants trade teaching and learning instead of stocks and bonds. “The financial market microstructure involves the study of how participants in financial markets of all kinds interact to transact with one another,” Huang said. “It has to do with questions like what are the trading costs, what structure would promote these transactions [and] what are the rules and regulations that are needed for a fair and orderly market.” Huang studied the international market system for his doctorate at the Wharton School of the University of Pennsylvania, and he said he sees the parallels between the market participants and the people involved in the educational system. “In fact, [the financial market microstructure] has a lot of relevance to what I’m doing today as dean in the sense that you talk about processes, about rules, protocols, best practices, operating rules and incentives,” Huang said. “We have multiple marketplace participants here, interactions between students and teachers, between staff and alumni and benefactors and supporters. “Of course, we are not transacting currencies or bonds and stocks, but here we are partaking in the learning process and how to best support the education process for our students.” Before coming to Notre Dame, Huang taught at Vanderbilt University, the University of Florida, the Massachusetts Institute of Technology and Purdue University. He said as a Catholic, Notre Dame has “a special place in [his] heart” and a connection with Woo first brought him to the University. “Carolyn Woo and I both came to the United States from Hong Kong in the same year, we both graduated from Purdue in the same year with our bachelor’s degrees,” Huang said. “We parted ways for awhile [after Purdue] and then Notre Dame brought us back together.” Huang said he was invited to give a seminar at Notre Dame, and when offered the chance to join the faculty, “it didn’t take much” to persuade him. Bloomberg Businessweek has ranked Mendoza’s undergraduate program as the nation’s number one for three consecutive years and the MBA program ranked 20th overall in their system. Huang said these numbers are not the foundation of the College’s identity, though, and Mendoza’s defining goal is to share the idea of commerce as service to mankind. “The vision or mission that was given to us by our founder [Cardinal John O’Hara] in 1921 is to make the world a better place,” he said. “When we teach our students, it’s not just about learning the tools of the trade, so to speak, but also how to use them properly for the benefit of society.” While other universities might express similar aims for their programs, Huang said Notre Dame is unique in its consistent commitment to this vision. “From the time we were founded until now, we have never wavered from our vision. It’s not a fashion thing for us,” Huang said. “Other schools have made this a calling card since, say, after 2008, saying they’re about business for good, … but we have been doing it long before it was fashionable, and we will do it when one day the other schools might abandon it.” During his time as interim dean, Huang finalized a partnership between Mendoza and Renmin University in Beijing, China, to train Chinese graduate students pursuing careers with nonprofit organizations. This partnership, part of Mendoza’s unique Master of Nonprofit Administration (MNA) program, will begin next year to bring students from Renmin to Notre Dame to complete a dual degree program. “In Mendoza, we have a competitive advantage in our Master of Nonprofit Administration program and we are very proud of the program,” Huang said. “It’s one of a very few that are housed within business schools in the United States, which is very important. Nonprofit organizations need to be profitable in order to be sustainable, hence the need to be able to understand business, so it is crucial to be housed in the business school.” Huang said the pilot program will be small at first, but Mendoza hopes to eventually accommodate between 12 and 20 students. “China nowadays is experiencing a huge growth in nonprofit organizations, and all the people over there need to have some training in nonprofit administration,” he said. “This program will enable them to participate in that quest.” Mendoza’s elite reputation among the nation’s business schools is exciting, Huang said, and he plans to leverage it to share O’Hara’s vision and give students an opportunity to make a difference in the business world. “I hope we share [with our students] a Notre Dame brand of business education that will give them not only the tools to change the world, but hopefully also the commitment to changing the world,” he said. “They can make the world a better place to live in with those tools, and that’s exactly the hope I have for them.”
Congress has allotted more than $2.5 million for research projects at the University of Georgia College of Agricultural and EnvironmentalSciences.The funding is included in the Fiscal Year 2001 AgriculturalAppropriations Bill, passed by the U.S. House of Representativeson Oct. 6 and the U.S. Senate on Oct. 18. The bill now goes toPresident Bill Clinton for his signature.Eight Projects FundedThe UGA CAES, in cooperation with various agricultural commodityand interest groups, submitted funding requests for eight researchprojects. All eight requests, which impact important Georgia commoditiessuch as peanuts, Vidalia onions and beef cattle, received $2.57million in congressional funding. The bill was supported by GeorgiaSenators Max Cleland (D-GA) and Zell Miller (D-GA) and CongressmanJack Kingston (R-GA).”We are encouraged by the commitment Congressman Kingstonand other members of Congress have for important agriculturalresearch that supports Georgia’s number one industry,” saidGale Buchanan, dean and director of the UGA CAES.Kingston, who serves on the Agricultural Appropriates Subcommittee,was instrumental in obtaining the research funds for the college.”Withthese funds, the University of Georgia’s College of Agriculturaland Environmental Sciences will remain one of the leading researchinstitutions in the country,” he said. “The projectswill help farmers find solutions to some of the problems theyface and go a long way in ensuring Georgia’s commodities remaincompetitive and strong.”Peanuts and OnionsThe bill will benefit two research programs for the peanutindustry. Some $500,000 is earmarked for research to reduce peanutfood allergy risks. This research will include breeding new peanutvarieties, collaborating on the development of vaccines for peanutallergies and reducing peanut allergy risks through marketing,handling and processing methods.The National Center for Peanut Competitiveness will receive$400,000 to support research on breeding pest- and disease-resistantpeanut varieties, studying the peanut’s health-promoting qualitiesand analyzing the industry to keep U.S. peanut farmers competitive.The center is a partnership between UGA CAES, Auburn University,the University of Florida, and the Alabama and Florida CooperativeExtension Services.Vidalia onion producers will get $250,000 to fund an intensivestudy on marketing and promoting Georgia’s specialty onion. Theproject will measure factors that determine the market demandfor Vidalia onions, both in the United States and abroad.Tomato Spotted Wilt and Water QualityThe bill also provides $250,000 to fight Tomato Spotted WiltVirus, a disease that causes an estimated $80 million to $100million in losses to peanuts, tobacco and other Georgia cropseach year.A research project focusing on non-point sources of water contaminationin Georgia’s lakes and streams will receive $300,000. Researcherswill pinpoint the sources of contaminants in 580 impaired streamsegments and develop a plan for reducing contaminants.Safer Food and Better BeefThe bill also provides $285,000 for improving the safety ofvegetables grown using animal manure as fertilizer. Manure cancontain pathogens that contaminate water and crops. Outbreaksof food-borne illness have been linked to eating organically grownlettuce, drinking fresh-pressed apple juice and swimming in manure-contaminatedlakes. CAES researchers, along with USDA scientists, will launchresearch on reducing the risk of spreading harmful microorganismsto crops through manure.The Alliance for Food Protection, a cooperative program betweenUGA and the University of Nebraska, will receive $300,000 to developand modify food processing and preservation methods. Such methodsensure our food safety by identifying undetected pathogens andchemicals on food and enhancing the quality of processed foods.The National Beef Cattle Genetic Evaluation (NCE) Program,another UGA cooperative program, will receive $285,000 to improvebeef production and quality through genetic improvements. TheNCE Research Consortium includes UGA, Colorado State University,Cornell University and Iowa State University. “These UGAprojects will be possible because of this funding are vital notonly to Georgia’s family farmers but to American agriculture asa whole,” Miller said . “I am anxious to expand theresearch being conducted at the university and I look forwardto its beneficial impact on the agriculture community.”
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York An alleged drug dealer who a Nassau County police officer shot for allegedly driving into the cop has been identified as a 22-year-old Oyster Bay man, authorities said.Officers stopped a vehicle driven by Leo Duchnowski on Horse Hollow Road but when the officer approached, the suspect tried to flee and hit the officer shortly after 10 p.m. Monday, police said.The officer, who was knocked to the ground with a knee injury, fired his gun at the driver as Duchnowski, who was struck by the gunfire, put the vehicle in reverse, police said.Both the officer and the suspect were taken to local hospitals for treatment of non-life threatening injuries.Duchnowski was charged with assault, reckless endangerment, criminal possession of a controlled substance, criminal sale of a controlled substance.He will be arraigned at a later date.